The evolution of oral anticoagulants

Blood clots can form where they aren't needed, and cause serious medical problems. This animation produced by Nature Reviews Cardiology and Nature Reviews Drug Discovery explores progress in the development of oral anticoagulants that target components of the blood coagulation cascade to inhibit blood clotting in high-risk patients, as well as recent advances with antidotes to reverse the effects of oral anticoagulants when necessary. Nature Reviews Cardiology (http://www.nature.com/nrcardio) and Nature Reviews Drug Discovery (http://www.nature.com/nrd) have full responsibility for all editorial content. This content is editorially independent of sponsors. See also: Nature Reviews Cardiology poster on 'Anticoagulant drugs' available at http://www.nature.com/nrcardio/posters/anticoagu ...